Fission yeast cell cycle mutants and the logic of eukaryotic cell cycle control
نویسندگان
چکیده
منابع مشابه
Polypeptide synthesis in cell cycle mutants of fission yeast.
The cell cycle of a growing cel is characterized by 3 main periodic events: DNA synthesis mitosis and cell division. These events generally lie in a dependent sequence, in which one event cannot occur unless preceding events have occurred. The existence of dependent sequences of events raises the possibility that at least some of the gene products involved in the events are synthesized in a dep...
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The replication and segregation of chromosomal DNA are the two most important events of the cell cycle, and in eukaryotes the initiation of both these processes is triggered by activation of one or more cyclin-dependent kinases (or CDKs). Whilst higher eukaryotes have multiple CDKs that regulate cell cycle progression, a single CDK regulates both S-phase and mitosis in the yeasts Schizosaccharo...
متن کاملModelling the fission yeast cell cycle.
The molecular networks regulating basic physiological processes in a cell can be converted into mathematical equations (eg differential equations) and solved by a computer. The division cycle of eukaryotic cells is an important example of such a control system, and fission yeast is an excellent test organism for the computational modelling approach. The mathematical model is tested by simulatin...
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A fundamental process in biology is the mechanism by which cells duplicate and divide to produce two identical daughter cells. The fission yeast, Schizosaccharomyces pombe, has proved to be an excellent model organism to study the role that gene expression plays in this process. The basic paradigm emerging is that a number of groups of genes are expressed in successive waves at different cell c...
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We have identified a novel human gene by virtue of its ability to complement the radl-1 checkpoint mutant of Schizosaccharomyces pombe. This gene, called RACH2, rescues the temperature-sensitive lethality of a radl-1 weel-50 double mutant of S. pombe. Expression of RACH2 in S. pombe radl-1 strains partially restores UV resistance to the radl-1 mutant strain. Expression of RACH2 in a radl-1 cdc2...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2020
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e20-10-0623